What would you cure with a 50 kb knock-in?
We’ve successfully knocked in a 50 kilobase multifunctional DNA insert into human induced pluripotent stem cells (iPSCs) using our proprietary TARGATT™ technology.
This milestone represents a significant advance in the size of DNA researchers can safely insert site-specifically into the human genome and get reliable expression from one or more expression cassettes. We’re excited to use this capability to empower cell therapy developers and accelerate the next generation of advanced therapies.