Intelligent Design of Living Systems: AAV, Lentivirus, RNA
LV Edge: Stable packaging and producer cell lines with model-guided DNA design, achieving lentiviral titers up to E9 TU/mL for clinically relevant CARs while reducing GMP plasmid requirements.
AAV Edge: Modular platform combining AI-designed payload optimization, including tissue-specific promoters, sequence optimization, and GOI silencing, with stable HEK293 producer cell lines achieving titers up to 6E12 vg/mL.
RNA Edge: Model-guided RNA sequence design to optimize expression and stability for RNA therapeutics.
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