PXB-mouse:
- Possess highly humanized liver with a human hepatocyte replacement of ~90%
- Histologically normal liver constitution, stable human albumin secretion for the lifespan of the mouse
- Functional human specific metabolic, transporter, and excretory pathways in the humanized liver
- Amenable to AAV transduction and LNP transfection in the model’s humanized liver (including AAVs typically only usable in Humans and NHPs)
- High-fat diet inducible NASH pathophysiology (fibrosis, steatosis, lobular inflammation, hepatocyte ballooning)
PXB-cells:
- Highly plateable and stable in culture for 30 days or more
- Greater than 95% human hepatocytes in purity
- Can be consistently supplied from the same hepatocyte donor for 2 - 3 years
- Available freshly plated in multiple options including 24-well, 96-well, 384-well, and T75 flask (for re-plating)
We also offer Custom Transplantation Services to through which we can use our mouse model to transplant the primary hepatocytes from other species (Rat, NHP, etc) as well diseased human patient derived hepatocytes for the development of novel rare disease models.