Gene Tools, LLC

Philomath,  OR 
United States

Morpholinos to block translation, modify splicing & more.

Gene Tools manufactures Morpholino oligos for blocking translation, modifying splicing or inhibiting miRNA activity.  Morpholinos are used in cell cultures, embryos or, as Vivo-Morpholinos, in adult animals.  Morpholinos are effective, specific, stable and non-toxic. Backed by Ph.D.-level customer support, Gene Tools designs and synthesizes Morpholinos and offers cytosolic delivery options.

Brands: Translation blocking oligos Splice modifying oligos miRNA inhibiting oligos Poly-A tail signal blocking oligos


  • Morpholino antisense oligos (PMO)
    Morpholino antisense oligos (or PMOs) are used in some approved drugs for Duchenne muscular dystrophy and by researchers for RNA manipulations. Applications include knockdown of translation, modifying pre-mRNA splicing or blocking miRNA activity.

  • A Morpholino oligo, or phosphorodiamidate morpholino oligo (PMO), is an uncharged oligo that binds complementary RNA.  Over 11,000 papers have been published reporting RNA manipulation with Morpholiinos.  There are several FDA-approved Morpholino drugs for Duchenne muscular dystrophy.

    Morpholinos are typically 25 bases in length, though this can be adjusted to optimize binding energy.  They consist of DNA bases on methylenemorpholine rings, linked through uncharged phosphorodiamidate linkages.  Morpholinos can be linked to various optional end-groups such as fluorescent tags, affinity tags, conjugation handles or a delivery moiety. Morpholinos have little affinity for proteins and are completely stable in cells and tissues.

    Gene Tools manufactures Morpholinos as well as Vivo-Morpholinos, a delivery-enabled form of the oligo with a terminal octaguanidinium dendrimer to help Morpholino oligos enter cells in cultures or in animals.  We also provide sequence design assistance and help with experiment planning.

    See our Morpholino publication database for examples of published Morpholino work: