Los Angeles Convention Center
Los Angeles, CA
May 16-20, 2023


Fargo,  ND 
United States

Aldevron welcomes you to the ASGCT Annual meeting!

Aldevron serves the biotechnology industry with custom production of nucleic acids and proteins. Thousands of clients use Aldevron-produced plasmids, RNA and gene editing enzymes for projects ranging from research grade to clinical trials to commercial applications. Aldevron specializes in cGMP manufacturing and is known for inventing the GMP-Source® quality system.

Aldevron operates the largest cGMP plasmid DNA manufacturing facility in the world at company headquarters in Fargo, North Dakota, with additional facilities in Madison, Wisconsin.


  • Nanoplasmidᵀᴹ - The Power of Small and Safe
    Looking to enhance performance and manufacturing from your DNA backbone, without the regulatory concerns? The Nanoplasmid Vector System (<500 bp backbone) provides advantages over existing legacy plasmid DNA backbones and minicircles.


  • Combining characteristics of reduced size and the RNA-OUT non-antibiotic resistance selection marker, the platform is suited for a range of therapeutic applications. Aldevron can provide customized Nanoplasmid DNA for each client. Nanoplasmid advantages include:

    • High Transgene Expression
    • Increased Manufacturing Yields
    • Improved Safety Profile by Eliminating Antibiotic Resistant Gene
    • Save Time and Cost-Effective

    Antibiotic-free selection provided by RNA-OUT
    The RNA-OUT platform works by repressing the expression of a counter-selectable marker (SacB) from the host chromosome. SacB encodes for the levansucrase enzyme, which creates a toxic environment in the presence of sucrose, which leads to cell death. Transforming the Antibiotic-free Nanoplasmid in the host expresses a 150bp RNA-OUT antisense RNA (ROUT) that binds the SacB mRNA and represses levansucrase expression, prevents toxicity and to maintain cell survival. The RNA-OUT selectable marker can be used to retrofit existing antibiotic resistance DNA plasmids into antibiotic-free vectors counter-selection system.

    Learn more about Nanoplasmids