Walter E. Washington Convention Center
Washington, D.C.
May 16-19, 2022

Touchlight DNA Services  

United Kingdom
  • Booth: 212

We look forward to meeting you at Booth 212 at ASGCT

DNA Manufacturing for advanced therapy production

Touchlight DNA Services provide rapid, enzymatic DNA development and manufacturing for all advanced therapy production, including mRNA, non-viral gene therapy, AAV, lentivirus, genome editing and DNA API.

Touchlight’s novel, synthetic DNA vector known as doggybone DNA (dbDNA™), is an antibiotic resistance free DNA vector with fast manufacturing timelines for research through to GMP applications.

dbDNA is a minimal, linear, covalently closed structure, that eliminates bacterial sequences. Touchlight’s revolutionary enzymatic production platform enables unprecedented speed, scale, and the ability to target genes with a size and complexity that is impossible with current technologies.

Clients can be supported from pre-clinical through development and supply, to licencing and tech transfer for use in-house.

How dbDNA can help you.

  • Reduced timelines
  • Improved quality, safety, and reliability
  • Avoidance of quality issues caused by complexity of sequence
  • Reduced costs at scale

Learn more about how doggybone DNA is made

Brands: doggybone DNA dbDNA

 Press Releases

  • Touchlight to break ground on world’s highest-capacity DNA manufacturing facility

    Touchlight, a biotechnology company pioneering enzymatic DNA production to enable the genetic medicine revolution, has received the first phase of planning approval for breaking ground on its new research and manufacturing facility in Hampton, UK.

    The project will include the repair and renovation of a key remaining part of the Morelands and Riverdale Buildings, a former Victorian water works on the River Thames. The facility will house 11 new state-of-the-art DNA production suites, bringing the total on site to 15 and more than tripling Touchlight’s London-based DNA manufacturing capacity.

    Touchlight’s expansion is in direct response to the growing global demand for DNA, driven in particular by the advent of mRNA and DNA vaccines, alongside cell and gene therapies. Once operational in 2022, the facility will have the capacity to manufacture up to 1 kilogram of GMP DNA per month, more than any other single site worldwide.

    Despite this significant production capacity, the benchtop scale of Touchlight’s proprietary dbDNA™ (“doggybone DNA”) manufacturing technology enables a total facility footprint of just 7,500 sq ft, a fraction of the space required by conventional bioreactor-based plasmid DNA manufacture.

    In addition to a significantly smaller footprint, Touchlight’s unique synthetic dbDNA platform offers numerous advantages over traditional plasmid DNA manufacture. Using enzymatic production, GMP dbDNA can be manufactured at unprecedented speed, scale and simplicity, with all bacterial sequences eliminated, allowing for improved safety and efficacy.

    This landmark building project will support Touchlight’s continued growth, alongside the addition of up to 60 new employees, through the provision of additional essential laboratory and office space. The building project is designed to respect, incorporate and sensitively build upon the heritage of the Hampton site, through the incorporation and integration of the state-of-the-art facility.

    Jonny Ohlson, Executive Chairman of Touchlight, said: “Touchlight was founded 14 years ago based on a belief that DNA was destined to underpin the next generation of medicines, and these have now truly come of age. The expansion of our Hampton facility is integral to our mission to support this genetic medicine revolution, meeting the explosion in demand for DNA by providing globally unrivalled manufacturing capacity.”

    Munira Wilson, MP for Twickenham, who visited Touchlight to support the project, commented: “It is fantastic to see the ongoing restoration of the Grade II listed Morelands and Riverdale Victorian pumping station in Hampton. Touchlight is bringing the buildings back to life and, while doing so, providing excellent local employment opportunities and playing a significant role in positioning the UK as a global leader in genetic medicines.”

    Learn more about Touchlight’s DNA manufacturing capabilities


  • Enzymatic DNA manufacturing and supply
    Rapid, enzymatic DNA development and manufacturing for all advanced therapy production, including mRNA, viral and non-viral gene therapy and DNA API. Clients can be supported from pre-clinical through to development and supply....

  • Touchlight's enzymatically produced DNA, called doggybone DNA (dbDNA) is a minimal, linear, covalently closed structure, which eliminates bacterial sequences. It can incorporate genes of interest up to 20kb making it very flexible to support a wide range of genetic medicines. The cell-free process avoids selective pressure often associated with plasmid instability, while also delivering rapid and reliable GMP DNA

    How dbDNA can help you.

    • Reduced timelines – dbDNA avoids prolonged fermentation queues by utilizing a cell-free enzymatic process. Enzymatic manufacturing enables scalable GMP DNA production in weeks rather than the months taken to make plasmid DNA.
    • Improved quality, safety, and reliability - dbDNA excludes bacterial sequences and antibiotic resistance genes, avoiding regulatory challenges associated with those sequences. dbDNA is also proven to be amplified with exceptionally high fidelity.
    • Avoidance of quality issues caused by complexity of sequence - dbDNA can amplify unstable sequences and produce difficult DNA. 
    • Reduced costs at scale – The cost of dbDNA production is predominantly driven by materials, and so the cost of DNA is significantly reduced at scale, while a higher copy number per gram than plasmid means less DNA is needed.

    Learn more about dbDNA 

    Access dbDNA in different ways.

    • Off-the-shelf catalogue products for initial evaluation.
    • Conduct a feasibility assessment with the supply of mg of dbDNA of your custom sequence of interest. This can be a quick and easy way to assess your product in the dbDNA platform.
    • Toxicology and cGMP material supply. Flexible supply and development to meet your scale and timeline.

    ​Learn more about Touchlight