The scale-X™ carbo system is a flexible, highly productive and GMP compatible platform for the production of viral products. It features a cell growth surface area of 10 or 30 m² which integrates in-line product concentration function. The scale-X carbo system is ideally placed for mid-scale production enabling process development and GMP manufacturing.
The system facilitates the development of a scalable process for transfer to the the scale-X nitro bioreactor (integrated into the NevoLine™ Upstream platform). It also enables clinical and commercial production in its own right with a full GMP offering.
The scale-X carbo controller integrates both cell culture (adherent and suspension cell lines) and product concentration.
This is achieved by combining the controls necessary to operate the fixed-bed bioreactor as well as to concentrate the product using in-line tangential flow filtration, all through the same interface.
The combination of two operations in one reduces the total volume of process material and the equipment footprint, contributing to reducing the product cost of goods.