MilliporeSigma, the life science business of Merck KgaA, Darmstadt, Germany, is an industry leader in the field of gene therapy with more than 30 years of experience and broad expertise across the entire workflow. We understand the unique pain points that innovators face, from optimizing upstream and downstream workflows to meeting accelerated manufacturing timelines and navigating new regulatory guidelines. We can proudly state that we were the first gene therapy CDMO to produce a commercial product following a successful regulatory inspection. Our global organization is ready to address your specific needs with an integrated, customizable offering.


 Products

  • BioReliance® Analytical Development Services
    Analytical development and method validation capabilities provide knowledge to develop a QTPP and identify the CQAs for your therapy
     ...

  • BioReliance® Biosafety Testing Services
    Our leading cGMP-compliant testing services and regulatory knowledge can help you progress your therapeutic from discover to release....

  • Viral Vector Development & Manufacturing Services
    Deep expertise & customized solutions for viral vector development and manufacturing to advance cell and gene therapies from preclinical through commercial production. ...

  • The Sf-RVN® Platform
    The SF-RVN Platform is a rhabdovirus-free platform that improves the safety profile of your gene therapy.
     ...

  • VirusExpress® Production Platform
    Offers a transfection-based solution to lentivirus or AAV production challenges, featuring a suspension adapted cell line and chemically defined medium
     ...

  • Cellvento® 4HEK medium
    With our Cellvento® 4HEK medium, you can produce higher AAV titers across multiple HEK293 cell lines.
     ...

  • Benzonase® endonuclease Safety Plus
    Benzonase® endonuclease can significantly reduce the levels of DNA by more the 100,000-fold ...

  • Pellicon® Capsule for VGT
    Our Pellicon® capsules are a true single-use solution for your TFF challenges.
     ...