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Fig. 1 | Mechanism-of-action of CT-001. This uniquely engineered, recombinant coagulation factor VIIa (rFVIIa) is administered intravenously. Gamma-carboxyglutamic acid (Gla)-domain amino-acid substitutions improve bleeding-site targeting and potency, accelerating clot formation. Unused CT-001 molecules are rapidly cleared from circulation via the recognition of exposed galactose residues by asialoglycoprotein receptors (ASGPRs) expressed on hepatocytes. CT-001’s enhanced efficacy and safety have been demonstrated in preclinical studies.

Stopping Acute Bleeds, Starting With Severe Postpartum Hemorrhage

Coagulant Therapeutics is developing a novel pipeline of therapeutics to treat acute bleeds led by CT-001, a next-generation factor VIIa (FVIIa) molecule. Read post
Sampling Human apoptosis kit

Sampling Human Ships its First Kits for Cellular Analysis to Early Access Customers and Releases an App Note with BMG LABTECH

Daniel Georgiev, co-founder and chief executive officer of Sampling Human, will be speaking on applications for the technology at the SynBioBeta conference. “At Sampling Human, we recognize the great lengths scientists go to today in order to obtain high-quality single-cell data,” said Daniel Georgiev. “Our plug and play products are designed to deliver reliable solutions with higher specificity, lower cost and ease of use for measuring the growing number of specialized cells in the body.” Read post
A large group of scientists point at the company's CEO

The Search for Useful Proteins: Berkeley Startup Aims To Turn Generative AI Into a Gene-Fixing Tool

AI-powered Profluent Bio released the world’s first open-source, AI-generated gene editor, the Berkeley company said Monday, an effort that could help more scientists develop CRISPR medicines to fix a range of diseases. Profluent, a roughly 20-person company launched by former Salesforce researcher Ali Madani and University of Washington assistant professor Alexander Meeske, said its OpenCRISPR-1 gene editor uses a protein, which it developed with large language models, and guide RNA that shuttles a cutting protein where it needs to go. Read post
Steve Lo

What Makes a Good CEO? Steve Lo, Former Valitor CEO, Has Answers

A “mentorship mentality” shapes the trajectory of aspiring leaders. By mentoring others, leaders not only hone their technical knowledge but also practice crucial soft skills such as effective communication. Moreover, mentorship fosters a sense of community and support, enabling CEOs to cultivate a strong network. Read post
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